Biophotonics across Energy, Space and Time
Multiscale Molecular Probes
Au/Ag uniaxial nanopetal structures on shrunk polystyrene sheets. Scale bars=10um and 2um (inset) Vertical cross-section of two photon excitation image of fluoroscein molecules on uniaxial nanopetals. Scale bar=5um

Figure 1a. Au/Ag uniaxial nanopetal structures on shrunk polystyrene sheets. Scale bars =10um and 2um (inset). Figure 1b. Vertical cross-section of two photon excitation image of fluoroscein molecules on uniaxial nanopetals. Scale bar=5um.

Novel molecular probes that act as sources of optical contrast or energy deposition, span, connect, and enable the multi-scale research efforts of the BEST IGERT program. In particular, BEST faculty in the Depts. of Biomedical Engineering, Chemical Engineering & Materials Science, and Chemistry are developing Biophotonic nanoscale technologies to address biological questions in ongoing research programs as well as to enable unprecedented biological investigations. Developing the connection between state-of-the-art nano-engineering with photonics and the biological sciences is critical to drive further probe development. The probes being leveraged by BEST span in-vitro single molecule detection to in vivo animal imaging with single-cell resolution for combined imaging and therapeutics. These tools can be applied for point-of-care diagnostics, disease detection, monitoring, and treatment as well as for fundamental understanding of photonic and biological processes.

BEST Faculty for Molecular Probes

Chen (Biomedical Engineering & Surgery), Khine (Biomedical Engineering, Mechanical and Aerospace Engineering, Kwon (Pharmaceutical Sciences and Chemical Engineering), Prescher (Chemistry, Molecular Biology & Biochemistry, Pharmaceutical Sciences)