Biophotonics across Energy, Space and Time
Biophotonics Modeling & Computation
Modeling and Computation

Modeling and computation are integral to the development and operation of nearly all Biophotonics technologies. Model-based computations of electromagnetic field propagation and radiative transport provide the basis for understanding the resolution and depth characteristics of optical microscopy, imaging, diagnostic, and treatment methods across all spatial and temporal scales in Biophotonics. BEST faculty are involved in developing modeling and computational methods to: (a) process and sharpen the quality of Biophotonic images; (b) gain greater understanding of the impact of tissue scattering on the limits of optical resolution and depth; (c) recovery of structural and functional information from wide-field and diffuse optical measurements; (d) guide the design of novel instrumentation; and (e) plan dosimetry in photothermal and photodynamic therapies. The need for development and access to Computational Biophotonics methods led to the formation of the Virtual Photonics Technology Initiative ( led by BEST PI Venugopalan and established within the NIH-funded P41 LAMMP Center at the Beckman Laser Institute. The BEST IGERT program provides numerous opportunities for trainees to develop, deliver, and apply advanced, efficient, and automated computational tools with real-time, multi-scale, dynamic optical modeling capabilities to Biophotonics researchers for imaging and analysis of complex biological systems.

Faculty for Modeling and Computation

Chen (Biomedical Engineering, Surgery), Potma (Chemistry, Surgery), Venugopalan (Chemical Engineering & Materials Science, Biomedical Engineering, Surgery), Zhao (Mathematics)