Biophotonics across Energy, Space and Time
Macroscale Biophotonics: Diffuse Optics
Diffuse Optics

Diffuse optics refers to a class of methods utilizing red and near-infrared, photons that have undergone multiple scattering interactions over millimeter to centimeter spatial scales. In this regime, light transport can be modeled as a diffusive process where photons behave as particles that move stochastically which can be modeled in a fashion similar to the diffusive transport of molecules or heat. Quantitative tissue measurements can be obtained by using these models to separate the differing effects of optical absorption and scattering on detected optical signals. This is most effectively achieved using spatially or temporally-modulated photon migration technologies, both of which were pioneered by BEST IGERT faculty. The underlying physical principle of these methods is based on the fact that light absorption events, which are a consequence of molecular interactions, are less likely to occur than light scattering. This is due to the fact that typical tissue near infrared absorption lengths are ~10 cm, while scattering lengths are ~20 ┬Ám. BEST trainees will have ample opportunity to develop and apply Diffuse optical technologies to numerous biomedical problems to understand and detect the appearance, progression, and therapeutic response of pathologies such as cancer, neurodegenerative disease, traumatic wounds, vascular disease, and musculoskeletal disease.

BEST Faculty for Diffuse Optics

Durkin (Surgery), Gratton (Biomedical Engineering, Physics & Astronomy), Gulsen (Radiological Sciences, Physics & Astronomy), Tromberg (Biomedical Engineering, Surgery)